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Rahuls99

Peptidomimetics in Organic and Medicinal Chemistry

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ef506b5f5f4aa2e7dc706653b91a0907.jpg [b]Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna and Andrea Trabocchi[/b] English | 2014 | ISBN: 1119950600 | 308 pages | PDF | 14 MB A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.7409461d53baf8ee6fe405f510a7faff.png [b]Buy Premium From My Links To Get Resumable Support,Max Speed & Support Me[/b]
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